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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TK1 All Species: 27.27
Human Site: Y61 Identified Species: 66.67
UniProt: P04183 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P04183 NP_003249.3 234 25469 Y61 K Y A K D T R Y S S S F C T H
Chimpanzee Pan troglodytes XP_001145198 309 32942 Y103 K Y A K D T R Y S S S F C T H
Rhesus Macaque Macaca mulatta XP_001107944 234 25438 Y61 K Y A K D T R Y S S S F C T H
Dog Lupus familis XP_540462 242 26432 Y61 K Y A K D T R Y S N S F S T H
Cat Felis silvestris
Mouse Mus musculus P04184 233 25757 Y61 K Y A K D T R Y S N S F S T H
Rat Rattus norvegicus P27158 121 13492
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001521037 255 27396 Y83 K Y A K D V R Y G H S F S T H
Chicken Gallus gallus P04047 224 24853 Y61 K Y A K D T R Y C T T G V S T
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_956126 230 25567 Y61 K Y A K D T R Y S C T G M A T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_784788 227 25150 L74 K A T S T S D L S S I A E L A
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 75.7 98.7 89.2 N.A. 87.1 47 N.A. 72.9 73 N.A. 65.8 N.A. N.A. N.A. N.A. 48.7
Protein Similarity: 100 75.7 99.1 90.9 N.A. 91.8 50 N.A. 78 82 N.A. 74.7 N.A. N.A. N.A. N.A. 62.8
P-Site Identity: 100 100 100 86.6 N.A. 86.6 0 N.A. 73.3 53.3 N.A. 60 N.A. N.A. N.A. N.A. 20
P-Site Similarity: 100 100 100 93.3 N.A. 93.3 0 N.A. 73.3 73.3 N.A. 66.6 N.A. N.A. N.A. N.A. 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 10 80 0 0 0 0 0 0 0 0 10 0 10 10 % A
% Cys: 0 0 0 0 0 0 0 0 10 10 0 0 30 0 0 % C
% Asp: 0 0 0 0 80 0 10 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 60 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 10 0 0 20 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 10 0 0 0 0 60 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 10 0 0 0 0 % I
% Lys: 90 0 0 80 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 0 0 0 0 10 0 0 0 0 0 10 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 20 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 80 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 10 0 10 0 0 70 40 60 0 30 10 0 % S
% Thr: 0 0 10 0 10 70 0 0 0 10 20 0 0 60 20 % T
% Val: 0 0 0 0 0 10 0 0 0 0 0 0 10 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 80 0 0 0 0 0 80 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _